Bills vs. Jaguars odds, prediction, time: NFL picks, Monday Night Football bets by model on 41-22-roll
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SportsLine's model simulated Buffalo Bills vs. Jacksonville Jaguars on Monday Night Football 10,000 times
By CBS Sports Staff
21 mins ago•4 min read
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After coming up short in their first two games, the Jacksonville Jaguars will try to pick up win No. 1 when they battle the Buffalo Bills in a key early-season AFC matchup on Monday Night Football. Jacksonville has been outscored by just eight points this season, while Buffalo has a plus-27 point differential. The Jaguars, who finished second in the AFC South at 9-8, one game behind the Houston Texans, were 6-6 within the conference in 2023. The Bills, winners of the past four AFC East division titles, went 7-5 against AFC opponents.
Kickoff from Highmark Stadium in Orchard Park, N.Y., is set for 7:30 p.m. ET. The Bills are 5.5-point favorites in the latest Jaguars vs. Bills odds, while the over/under for total points scored is 45.5. Before making any Bills vs. Jaguars picks, be sure to see the NFL predictions and betting advice from SportsLine's proven computer model.
The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 3 of the 2024 NFL season on an incredible 187-130 run on top-rated NFL picks that dates back to the 2017 season. It is also on a 41-22 roll on top-rated NFL picks since Week 7 of 2022.
The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.
Now, the model has set its sights on Jaguars vs. Bills and just locked in its picks and NFL predictions. You can head to SportsLine now to see the model's picks. Here are several NFL odds and NFL betting lines for the spread, money line and over/under for Bills vs. Jaguars:
Jaguars vs. Bills spread: Buffalo -5.5
Jaguars vs. Bills over-under: 45.5 points
Jaguars vs. Bills money line: Buffalo -250, Jacksonville +203
JAC: Jaguars have covered the third-quarter spread in 12 of their last 17 games (+6.75 units)
BUF: Bills have hit the third-quarter money line in 11 of their last 19 games
Jaguars vs. Bills picks: See picks at SportsLine
Why you should back the Bills
Quarterback Josh Allen passed for 139 yards and a touchdown with no interceptions for a 107.1 rating in Week 2, his third week in a row with a 100-plus rating and a passing touchdown. He had 373 total yards and three total touchdowns in the last meeting with Jacksonville. Allen has 40 career games, including the playoffs, with a passing and rushing touchdown, the second-most in NFL history (Cam Newton had 46). Allen has 300 or more passing yards and three-plus TDs for a 105 or better rating in four of seven Monday Night Football starts.
Running back James Cook had a solid game in the win over Miami. He had 95 yards from scrimmage (78 rushing and 17 receiving) and three touchdowns (two rushing and one receiving), the second-most in the NFL in Week 2. Cook has 100 or more scrimmage yards in four of his past five games at home. He will look for his fourth prime time game in a row at home with 70-plus scrimmage yards. See which team to pick here.
Why you should back the Jaguars
Quarterback Trevor Lawrence passed for 220 yards with zero interceptions and rushed for 45 yards in last week's loss. He will be looking for his third game in a row with no interceptions. He has had Buffalo's number, going 2-0 in two career starts against them. He passed for 315 yards and a touchdown with no interceptions with a 102.9 rating in the last meeting. He has eight touchdowns (five passing and three rushing) with no interceptions and a 96.3 rating in six career starts in primetime.
Running back Travis Etienne rushed for 52 yards and a touchdown in last week's game and is one of four players in the AFC with a rushing touchdown in each of the first two weeks of the season. Etienne will look for his fifth game in a row with 55 or more yards from scrimmage. He had a career-high 184 scrimmage yards (136 rushing and 48 receiving) and two rushing TDs in the last meeting with Buffalo. He has three rushing touchdowns in his past three games in primetime. See which team to pick here.